Blood Brain Barrier: The Sentinel of Brain

Introduction: The blood-brain barrier (BBB) plays a major role in controlling the microenvironment of the brain. Drug delivery to the brain is restricted by the presence of the BBB. It is actually selectively permeable to nutrients necessary for healthy brain function. Material and Methods: Various search engines like pubmed , medline and cochrane database were searched for various articles. Result and Conclusion : Prodrugs with increased lipophilicity and Chemical delivery system(CMD) are under research. A diverse collection of molecular transport systems is present on the brain endothelium to accomplish the task of nutrient transport. Receptor-mediated transcytosis (RMT) systems can be used to transport a wide range of therapeutics into the brain.Molecular identification and functional analysis of influx transport proteins and efflux transport proteins, the most active being ABC-transporters (ATP binding cassette) at BBB have progressed rapidly. This review focuses on the role of Increased understanding of the pharmacology of the transport systems in the uptake of xenobiotics across the BBB into the brain for rational drug design to increase drug delivery to the brain .